The classification of biological agents in this document is an Approved List made under Section 15 of the Health and Safety at Work etc Act 1974. The Control of Substances Hazardous to Health Regulations 2002 (COSHH), by making reference to this list, impose requirements which are legally binding. The Notice of Approval signed by the Secretary to the Health and Safety Commission signals its legal status. The list implements the Community Classification of biological agents set out in European Community Directive 2000/54/EC.