Current Treatment Options in Infectious Diseases 2003; 5: 517-527
ISSN: 1523-3820
Contenido:

Invasive aspergillosis is an increasing cause of infectious morbidity after hematopoietic stem cell transplantation (HSCT) and has a high case fatality rate. It is the main infectious challenge to HSCT clinicians. Reasons cited for poor treatment outcomes include difficulty in accurate diagnosis, which frequently results in late start of therapy, and therapies that are highly toxic or suboptimally effective. New diagnostics, including antigen assays such as galactomannan and beta glucan, and polymerase chain reaction assays offer hope that noninvasive means will make an early diagnosis in the course of infection. New therapies such as voriconazole for first- or second-line treatment, or caspofungin for second-line therapy, offer promise for less toxic and more efficacious therapies.
Wingard, J.R. y Leather, H.