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Aims of this guide

1/ This guidance aims to expand and explain the legal requirements for working
with high-hazard pathogens, with a particular focus on the way in which these
requirements influence the design, construction and operation of CL4 facilities. This guidance is intended for all laboratories in which high-hazard pathogens may be handled. Additional guidance covering the clinical care of patients suspected of being infected with such pathogens can be found in other ACDP guidance.

2/In addition to providing practical guidance on how to meet the requirements
of specific legislation, this document also provides advice on good practice in
related aspects of design, operation and management of such facilities.

3/Details of some DEFRA CL4 containment and operating requirements for
work with specified animal pathogens under SAPO licences are included
throughout this guidance for comparative purposes, but the full range of DEFRA
CL4 requirements are not covered. For further details of these please refer to
DEFRA?s website (www.defra.gov.uk).