Tuberculosis infectioncontrol in hospitals has received renewed interest after decades of low prominence following the occurrence of multiply drug-resistant strains in populations of patients with immune systems affected by HIV. This paper examines the history of tuberculosis infectioncontrol in hospitals and how recent outbreaks have influenced contemporary measures. The prinicipal infectioncontrol measure must always be early recognition and isolation of patients in HIV-care situations who may be dispersing Mycobacterium tuberculosis, in both ward and outpatient areas. If there is either a high degree of suspicion or proven TB, patients should be housed in negative pressure isolation rooms whilst undergoing treatment and investigation. Procedures which may generate infectious aerosols should be carried out in similarly ventilated rooms. The quality assurance in such infectioncontrol is through the administrative systems put in place, staff training and the engineering controls of isolation room ventilation.